Polymorphisms of IL23R and Fuchs' syndrome in a Chinese Han population.

ABSTRACT:

Purpose

The aim of the study was to investigate the association of polymorphisms of the interleukin-23 receptor (IL23R) gene with Fuchs' syndrome in a Chinese Han population.

Methods

Three single-nucleotide polymorphisms (SNPs), rs7517847, rs11209032 and rs17375018 of IL23R were genotyped in 138 Chinese Han patients with Fuchs' syndrome and 407 healthy controls by using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Data were analyzed by χ(2) analysis.

Results

All genotype and allele distributions in patients with Fuchs' syndrome and healthy controls were in Hardy-Weinberg equilibrium. The frequency of the rs11209032 AA genotype was significantly increased in patients with Fuchs' syndrome as compared to controls (corrected p

SUBMITTER: Zhou H 

PROVIDER: S-EPMC3000233 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature