Stable and dynamic cortical electrophysiology of induction and emergence with propofol anesthesia.

ABSTRACT: The mechanism(s) by which anesthetics reversibly suppress consciousness are incompletely understood. Previous functional imaging studies demonstrated dynamic changes in thalamic and cortical metabolic activity, as well as the maintained presence of metabolically defined functional networks despite the loss of consciousness. However, the invasive electrophysiology associated with these observations has yet to be studied. By recording electrical activity directly from the cortical surface, electrocorticography (ECoG) provides a powerful method to integrate spatial, temporal, and spectral features of cortical electrophysiology not possible with noninvasive approaches. In this study, we report a unique comprehensive recording of invasive human cortical physiology during both induction and emer

SUBMITTER: Breshears JD 

PROVIDER: S-EPMC3000270 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature