Common microRNA signatures in cardiac hypertrophic and atrophic remodeling induced by changes in hemodynamic load.

ABSTRACT:

Background

Mechanical overload leads to cardiac hypertrophy and mechanical unloading to cardiac atrophy. Both conditions produce similar transcriptional changes including a re-expression of fetal genes, despite obvious differences in phenotype. MicroRNAs (miRNAs) are discussed as superordinate regulators of global gene networks acting mainly at the translational level. Here, we hypothesized that defined sets of miRNAs may determine the direction of cardiomyocyte plasticity responses.

Methodology/principal findings

We employed ascending aortic stenosis (AS) and heterotopic heart transplantation (HTX) in syngenic Lewis rats to induce mechanical overloading and unloading, respectively. Heart weight was 26±3% higher in AS (n = 7) and 33±2% lower in HTX (n = 7) as compared to sha

SUBMITTER: El-Armouche A 

PROVIDER: S-EPMC3000324 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature