Polymorphisms in genes involved in the estrogen pathway and mammographic density.

ABSTRACT:

Background

Single nucleotide polymorphisms (SNPs) in genes involved in the estrogen pathway appear to be associated with breast cancer risk and possibly with mammographic density (MD), but little is known of these associations among premenopausal women. This study examines the association of 11 polymorphisms in five estrogen-related genes (estrogen receptors alpha and beta (ERα, ERβ), 17β-hydroxysteroid dehydrogenase 1 (HSD17B1), catechol-O-methyltransferase (COMT), cytochrome P450 1B1 (CYP1B1)) with premenopausal MD. Effect modification of four estrogen-related factors (parity, age at menarche, hormonal derivatives use and body mass index (BMI)) on this relation is also assessed.

Methods

Polymorphisms were genotyped in 741 premenopausal Caucasian women whose MD was measured

SUBMITTER: Dumas I 

PROVIDER: S-EPMC3000407 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature