A randomized add-on trial of an N-methyl-D-aspartate antagonist in treatment-resistant bipolar depression.

ABSTRACT:

Context

Existing therapies for bipolar depression have a considerable lag of onset of action. Pharmacological strategies that produce rapid antidepressant effects-for instance, within a few hours or days-would have an enormous impact on patient care and public health.

Objective

To determine whether an N-methyl-D-aspartate-receptor antagonist produces rapid antidepressant effects in subjects with bipolar depression.

Design

A randomized, placebo-controlled, double-blind, crossover, add-on study conducted from October 2006 to June 2009.

Setting

Mood Disorders Research Unit at the National Institute of Mental Health, Bethesda, Maryland. Patients Eighteen subjects with DSM-IV bipolar depression (treatment-resistant).

Interventions

Subjects maintained at thera

SUBMITTER: Diazgranados N 

PROVIDER: S-EPMC3000408 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature