A genome-wide association study of amygdala activation in youths with and without bipolar disorder.

ABSTRACT:

Objective

Functional magnetic resonance imaging is commonly used to characterize brain activity underlying a variety of psychiatric disorders. A previous functional magnetic resonance imaging study found that amygdala activation during a face-processing task differed between pediatric patients with bipolar disorder (BD) and healthy controls. We undertook a genome-wide association study to explore the genetic architecture of this neuroimaging phenotype.

Method

Thirty-nine patients with BD and 29 healthy controls who had previously undergone functional magnetic resonance imaging when viewing a neutral face were genotyped using a genome-wide single-nucleotide polymorphism (SNP) array. After quality control, 104,043 SNPs were tested against normalized amygdala activation scores

SUBMITTER: Liu X 

PROVIDER: S-EPMC3000434 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature