The MBL2 'LYQA secretor' haplotype is an independent predictor of postoperative myocardial infarction in whites undergoing coronary artery bypass graft surgery.

ABSTRACT:

Background

Mannose-binding lectin (MBL) is an important component of innate immunity and activator of the lectin complement pathway. Within the MBL2 gene are seven 5' "secretor" haplotypes that code for altered serum MBL levels and complement activation. However, recent evidence suggests that 3' MBL2 haplotypes may also modify MBL function and circulating levels. Because MBL and the lectin complement pathway have been implicated in cardiovascular injury, we investigated whether MBL2 haplotypes are independently associated with an increased risk of postoperative myocardial infarction (PMI) in patients undergoing coronary artery bypass graft surgery.

Methods and results

Genotyping of 18 polymorphic sites within the MBL2 gene was performed in a prospective, longitudinal multi-i

SUBMITTER: Collard CD 

PROVIDER: S-EPMC3000829 | biostudies-literature | 2007 Sep

REPOSITORIES: biostudies-literature