DC-ATLAS: a systems biology resource to dissect receptor specific signal transduction in dendritic cells.

ABSTRACT:

Background

The advent of Systems Biology has been accompanied by the blooming of pathway databases. Currently pathways are defined generically with respect to the organ or cell type where a reaction takes place. The cell type specificity of the reactions is the foundation of immunological research, and capturing this specificity is of paramount importance when using pathway-based analyses to decipher complex immunological datasets. Here, we present DC-ATLAS, a novel and versatile resource for the interpretation of high-throughput data generated perturbing the signaling network of dendritic cells (DCs).

Results

Pathways are annotated using a novel data model, the Biological Connection Markup Language (BCML), a SBGN-compliant data format developed to store the large amount of

SUBMITTER: Cavalieri D 

PROVIDER: S-EPMC3000836 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature