Clinical effects and brain metabolic correlates in non-invasive cortical neuromodulation for visceral pain.

ABSTRACT:

Background and aims

Chronic visceral pain is frequent, extremely debilitating, and generally resistant to pharmacological treatment. It has been shown that chronic visceral inflammation, through altered afferent visceral sensory input, leads to plastic changes in the central nervous system that ultimately sustain pain. Therefore approaches aiming at modulation of brain activity are attractive candidates to control visceral pain.

Methods

Here we report findings of a phase II, sham-controlled clinical trial assessing the clinical effects and brain metabolic correlates of a 10-day course of daily sessions of slow-frequency, repetitive transcranial magnetic stimulation (rTMS) targeting the right secondary somatosensory cortex (SII) in patients with chronic pancreatitis and sever

SUBMITTER: Fregni F 

PROVIDER: S-EPMC3000866 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature