Identification of a novel susceptibility locus for juvenile idiopathic arthritis by genome-wide association analysis.

ABSTRACT:

Objective

Juvenile idiopathic arthritis (JIA) is a chronic rheumatic disease of childhood. Two well-established genetic factors known to contribute to JIA susceptibility, HLA and PTPN22, account for less than half of the genetic susceptibility to disease; therefore, additional genetic factors have yet to be identified. The purpose of this study was to perform a systematic search of the genome to identify novel susceptibility loci for JIA.

Methods

A genome-wide association study using Affymetrix GeneChip 100K arrays was performed in a discovery cohort (279 cases and 184 controls). Single-nucleotide polymorphisms (SNPs) showing the most significant differences between cases and controls were then genotyped in a validation sample of cases (n = 321) and controls, combined with c

SUBMITTER: Hinks A 

PROVIDER: S-EPMC3001111 | biostudies-literature | 2009 Jan

REPOSITORIES: biostudies-literature