A risk allele for focal segmental glomerulosclerosis in African Americans is located within a region containing APOL1 and MYH9.

ABSTRACT: Genetic variation at the MYH9 locus is linked to the high incidence of focal segmental glomerulosclerosis (FSGS) and non-diabetic end-stage renal disease among African Americans. To further define risk alleles with FSGS we performed a genome-wide association analysis using more than one million single-nucleotide polymorphisms in 56 African-American and 61 European-American patients with biopsy-confirmed FSGS. Results were compared to 1641 European Americans and 1800 African Americans as unselected controls. While no association was observed in the cohort of European Americans, the case-control comparison of African Americans found variants within a 60 kb region of chromosome 22 containing part of the APOL1 and MYH9 genes associated with increased risk of FSGS. This region spans different l

SUBMITTER: Genovese G 

PROVIDER: S-EPMC3001190 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature