Pulmonary vascular dysfunction is associated with poor outcomes in patients with acute lung injury.

ABSTRACT:

Rationale

Despite the recognition that acute lung injury (ALI) can elevate pulmonary artery (PA) pressure and right ventricular afterload, the impact of pulmonary vascular dysfunction on outcomes of these patients is not well defined.

Objectives

To investigate the impact of pulmonary vascular dysfunction in patients with acute lung injury.

Methods

Secondary analysis of the Fluid and Catheter Treatment Trial. A total of 501 patients who received a PA catheter were evaluated for associations between increases in transpulmonary gradient (TPG) (PA mean pressure - PA occlusion pressure) or pulmonary vascular resistance index (PVRi) and 60-day mortality, ventilator-, intensive care unit (ICU)-, and cardiovascular-free days (days with mean arterial pressure ≥ 60 mm Hg off va

SUBMITTER: Bull TM 

PROVIDER: S-EPMC3001255 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature