Somatic chromosome abnormalities in the lungs of patients with pulmonary arterial hypertension.

ABSTRACT:

Rationale

Vascular remodeling in pulmonary arterial hypertension (PAH) involves proliferation and migration of endothelial and smooth muscle cells, leading to obliterative vascular lesions. Previous studies have indicated that the endothelial cell proliferation is quasineoplastic, with evidence of monoclonality and instability of short DNA microsatellite sequences.

Objectives

To assess whether there is larger-scale genomic instability.

Methods

We performed genome-wide microarray copy number analysis on pulmonary artery endothelial cells and smooth muscle cells isolated from the lungs of patients with PAH.

Measurements and main results

Mosaic chromosomal abnormalities were detected in PAEC cultures from five of nine PAH lungs but not in normal (n = 8) or disease

SUBMITTER: Aldred MA 

PROVIDER: S-EPMC3001257 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature