Apolipoprotein E negatively regulates house dust mite-induced asthma via a low-density lipoprotein receptor-mediated pathway.

ABSTRACT:

Rationale

Distinct sets of corticosteroid-unresponsive genes modulate disease severity in asthma.

Objectives

To identify corticosteroid-unresponsive genes that provide new insights into disease pathogenesis and asthma therapeutics.

Methods

Experimental murine asthma was induced by nasal administration of house dust mite for 5 days per week. Dexamethasone and apolipoprotein E (apo E) mimetic peptides were administered via osmotic minipumps.

Measurements and main results

Genome-wide expression profiling of the lung transcriptome in a house dust mite-induced model of murine asthma identified increases in apo E mRNA levels that persisted despite corticosteroid treatment. House dust mite-challenged apo E⁻(/)⁻ mice displayed enhanced airway hyperreactivity and goblet

SUBMITTER: Yao X 

PROVIDER: S-EPMC3001262 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature