Apelin attenuates hyperoxic lung and heart injury in neonatal rats.

ABSTRACT:

Rationale

Apelin, a potent vasodilator and angiogenic factor, may be a novel therapeutic agent in neonatal chronic lung disease, including bronchopulmonary dysplasia.

Objectives

To determine the beneficial effect of apelin in neonatal rats with hyperoxia-induced lung injury, a model for premature infants with bronchopulmonary dysplasia.

Methods

The cardiopulmonary effects of apelin treatment (62 μg/kg/d) were studied in neonatal rats by exposure to 100% oxygen, using two treatment strategies: early concurrent treatment during continuous exposure to hyperoxia for 10 days and late treatment and recovery in which treatment was started on Day 6 after hyperoxic injury for 9 days and continued during the 9-day recovery period. We investigated in both models the role of the

SUBMITTER: Visser YP 

PROVIDER: S-EPMC3001263 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature