Safety and T cell modulating effects of high dose vitamin D3 supplementation in multiple sclerosis.

ABSTRACT:

Background

A poor vitamin D status has been associated with a high disease activity of multiple sclerosis (MS). Recently, we described associations between vitamin D status and peripheral T cell characteristics in relapsing remitting MS (RRMS) patients. In the present study, we studied the effects of high dose vitamin D3 supplementation on safety and T cell related outcome measures.

Methodology/principal findings

Fifteen RRMS patients were supplemented with 20,000 IU/d vitamin D3 for 12 weeks. Vitamin D and calcium metabolism were carefully monitored, and T cell characteristics were studied by flowcytometry. All patients finished the protocol without side-effects, hypercalcaemia, or hypercalciuria. The median vitamin D status increased from 50 nmol/L (31-175) at week 0 to 38

SUBMITTER: Smolders J 

PROVIDER: S-EPMC3001453 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature