Thermodynamics of competitive molecular channel transport: application to artificial nuclear pores.

ABSTRACT: In an analytical model channel transport is analyzed as a function of key parameters, determining efficiency and selectivity of particle transport in a competitive molecular environment. These key parameters are the concentration of particles, solvent-channel exchange dynamics, as well as particle-in-channel- and interparticle interaction. These parameters are explicitly related to translocation dynamics and channel occupation probability. Slowing down the exchange dynamics at the channel ends, or elevating the particle concentration reduces the in-channel binding strength necessary to maintain maximum transport. Optimized in-channel interaction may even shift from binding to repulsion. A simple equation gives the interrelation of access dynamics and concentration at this transition point.

SUBMITTER: Bauer WR 

PROVIDER: S-EPMC3001458 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature