FYVE-dependent endosomal targeting of an arrestin-related protein in amoeba.

ABSTRACT:

Background

Visual and β-arrestins are scaffolding proteins involved in the regulation of receptor-dependent intracellular signaling and their trafficking. The arrestin superfamilly includes several arrestin domain-containing proteins and the structurally related protein Vps26. In Dictyostelium discoideum, the arrestin-domain containing proteins form a family of six members, namely AdcA to -F. In contrast to canonical arrestins, Dictyostelium Adc proteins show a more complex architecture, as they possess, in addition to the arrestin core, other domains, such as C2, FYVE, LIM, MIT and SAM, which potentially mediate selective interactions with either lipids or proteins.

Methodology and principal findings

A detailed analysis of AdcA has been performed. AdcA extends on both sides

SUBMITTER: Guetta D 

PROVIDER: S-EPMC3001460 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature