Vitamin D receptor gene polymorphisms are associated with adiposity phenotypes.

ABSTRACT:

Background

Emerging data suggest a role for the vitamin D receptor (VDR) in lipogenesis and adipocyte differentiation.

Objective

Our objective was to evaluate the association of VDR gene variants and adiposity phenotypes in an epidemiologic study.

Design

In a sample of 1773 healthy female adults recruited from western New York, we tested for the association of 14 VDR single nucleotide polymorphisms (SNPs) with the following 3 adiposity phenotypes: body mass index (in kg/m²), waist circumference (in cm), and abdominal height (in cm). We examined age, education, total energy intake, smoking status, alcohol intake, and menopausal status as potential covariates.

Results

One SNP, rs3782905, remained associated with all 3 adiposity phenotypes after multiple-testing c

SUBMITTER: Ochs-Balcom HM 

PROVIDER: S-EPMC3001595 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature