Genetic variants in the TIRAP gene are associated with increased risk of sepsis-associated acute lung injury.

ABSTRACT:

Background

Toll like receptors (TLRs) signaling pathways, including the adaptor protein Mal encoded by the TIRAP gene, play a central role in the development of acute lung injury (ALI). Recently, the TIRAP variants have been described association with susceptibility to inflammatory diseases. The aim of this study was to investigate whether genetic variants in TIRAP are associated with the development of ALI.

Methods

A case-control collection from Han Chinese of 298 healthy subjects, 278 sepsis-associated ALI and 288 sepsis alone patients were included. Three tag single nucleotide polymorphisms (SNPs) of the TIRAP gene and two additional SNPs that have previously showed association with susceptibility to other inflammatory diseases were genotyped by direct sequencing. The dif

SUBMITTER: Song Z 

PROVIDER: S-EPMC3001691 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature