CAMP/PKA signaling balances respiratory activity with mitochondria dependent apoptosis via transcriptional regulation.

ABSTRACT:

Background

Appropriate control of mitochondrial function, morphology and biogenesis are crucial determinants of the general health of eukaryotic cells. It is therefore imperative that we understand the mechanisms that co-ordinate mitochondrial function with environmental signaling systems. The regulation of yeast mitochondrial function in response to nutritional change can be modulated by PKA activity. Unregulated PKA activity can lead to the production of mitochondria that are prone to the production of ROS, and an apoptotic form of cell death.

Results

We present evidence that mitochondria are sensitive to the level of cAMP/PKA signaling and can respond by modulating levels of respiratory activity or committing to self execution. The inappropriate activation of one of the y

SUBMITTER: Leadsham JE 

PROVIDER: S-EPMC3001716 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature