Long descending cervical propriospinal neurons differ from thoracic propriospinal neurons in response to low thoracic spinal injury.

ABSTRACT:

Background

Propriospinal neurons, with axonal projections intrinsic to the spinal cord, have shown a greater regenerative response than supraspinal neurons after axotomy due to spinal cord injury (SCI). Our previous work focused on the response of axotomized short thoracic propriospinal (TPS) neurons following a low thoracic SCI (T9 spinal transection or moderate spinal contusion injury) in the rat. The present investigation analyzes the intrinsic response of cervical propriospinal neurons having long descending axons which project into the lumbosacral enlargement, long descending propriospinal tract (LDPT) axons. These neurons also were axotomized by T9 spinal injury in the same animals used in our previous study.

Results

Utilizing laser microdissection (LMD), qRT-PCR, and

SUBMITTER: Siebert JR 

PROVIDER: S-EPMC3001741 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature