Symmetrical choline-derived dications display strong anti-kinetoplastid activity.

ABSTRACT:

Objectives

to investigate the anti-kinetoplastid activity of choline-derived analogues with previously reported antimalarial efficacy.

Methods

from an existing choline analogue library, seven antimalarial compounds, representative of the first-, second- and third-generation analogues previously developed, were assessed for activity against Trypanosoma and Leishmania spp. Using a variety of techniques, the effects of choline analogue exposure on the parasites were documented and a preliminary investigation of their mode of action was performed.

Results

the activities of choline-derived compounds against Trypanosoma brucei and Leishmania mexicana were determined. The compounds displayed promising anti-kinetoplastid activity, particularly against T. brucei, to which 4/7

SUBMITTER: Ibrahim HM 

PROVIDER: S-EPMC3001849 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature