Achiral bis-imine in combination with CoCl₂: A remarkable effect on enantioselectivity of lipase-mediated acetylation of racemic secondary alcohol.

ABSTRACT: A bis-imine (prepared via a new FeCl₃-based method) in combination with CoCl₂ facilitated lipase-mediated acetylation of the (R)-isomer of a racemic benzylic secondary alcohol with 91% ee(s). The methodology was used for the preparation of the known drug rivastigmine.

SUBMITTER: Arunkumar K 

PROVIDER: S-EPMC3002020 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature