Integrated analysis of mutations, miRNA and mRNA expression in glioblastoma.

ABSTRACT:

Background

Glioblastoma arises from complex interactions between a variety of genetic alterations and environmental perturbations. Little attention has been paid to understanding how genetic variations, altered gene expression and microRNA (miRNA) expression are integrated into networks which act together to alter regulation and finally lead to the emergence of complex phenotypes and glioblastoma.

Results

We identified association of somatic mutations in 14 genes with glioblastoma, of which 8 genes are newly identified, and association of loss of heterozygosity (LOH) is identified in 11 genes with glioblastoma, of which 9 genes are newly discovered. By gene coexpression network analysis, we identified 15 genes essential to the function of the network, most of which are cance

SUBMITTER: Dong H 

PROVIDER: S-EPMC3002314 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature