Investigation of type 1 diabetes and coeliac disease susceptibility loci for association with juvenile idiopathic arthritis.

ABSTRACT:

Background

There is strong evidence suggesting that juvenile idiopathic arthritis (JIA) shares many susceptibility loci with other autoimmune diseases.

Objective

To investigate variants robustly associated with type 1 diabetes (T1D) or coeliac disease (CD) for association with JIA.

Methods

Sixteen single-nucleotide polymorphisms (SNPs) already identified as susceptibility loci for T1D/CD were selected for genotyping in patients with JIA (n=1054) and healthy controls (n=3129). Genotype and allele frequencies were compared using the Cochrane-Armitage trend test implemented in PLINK.

Results

One SNP in the LPP gene, rs1464510, showed significant association with JIA (p(trend)=0.002, OR=1.18, 95% CI 1.06 to 1.30). A second SNP, rs653178 in ATXN2, also showed nomina

SUBMITTER: Hinks A 

PROVIDER: S-EPMC3002762 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature