Cardiac-specific leptin receptor deletion exacerbates ischaemic heart failure in mice.

ABSTRACT:

Aims

the obesity-related adipokine, leptin, has multiple actions on peripheral organs, including the mitigation of adverse cardiovascular outcomes after myocardial infarction (MI). Although we recently demonstrated that leptin, its receptor, and downstream signalling are up-regulated in the heart after MI, the significance of intact cardiomyoctye leptin signalling is unknown. Therefore, our objective was to generate a cardiomyocyte-specific leptin receptor knock-out (ObRKO) mouse to determine whether worse cardiac outcomes after MI result from impaired leptin signalling in cardiomyocytes.

Methods and results

tamoxifen-inducible ObRKO mice were subjected to experimental MI or sham surgeries and studied after 1 month. After MI, ObRKO mice displayed a loss of cardiac signal tra

SUBMITTER: McGaffin KR 

PROVIDER: S-EPMC3002875 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature