Functional comparison of innate immune signaling pathways in primates.

ABSTRACT: Humans respond differently than other primates to a large number of infections. Differences in susceptibility to infectious agents between humans and other primates are probably due to inter-species differences in immune response to infection. Consistent with that notion, genes involved in immunity-related processes are strongly enriched among recent targets of positive selection in primates, suggesting that immune responses evolve rapidly, yet providing only indirect evidence for possible inter-species functional differences. To directly compare immune responses among primates, we stimulated primary monocytes from humans, chimpanzees, and rhesus macaques with lipopolysaccharide (LPS) and studied the ensuing time-course regulatory responses. We find that, while the universal Toll-like rece

SUBMITTER: Barreiro LB 

PROVIDER: S-EPMC3002988 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature