Facilitation of long-term potentiation by muscarinic M(1) receptors is mediated by inhibition of SK channels.

ABSTRACT: Muscarinic receptor activation facilitates the induction of synaptic plasticity and enhances cognitive function. However, the specific muscarinic receptor subtype involved and the critical intracellular signaling pathways engaged have remained controversial. Here, we show that the recently discovered highly selective allosteric M(1) receptor agonist 77-LH-28-1 facilitates long-term potentiation (LTP) induced by theta burst stimulation at Schaffer collateral synapses in the hippocampus. Similarly, release of acetylcholine by stimulation of cholinergic fibers facilitates LTP via activation of M(1) receptors. N-methyl-D-aspartate receptor (NMDAR) opening during theta burst stimulation was enhanced by M(1) receptor activation, indicating this is the mechanism for LTP facilitation. M(1) recepto

SUBMITTER: Buchanan KA 

PROVIDER: S-EPMC3003154 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature