Ontology highlight
ABSTRACT:
SUBMITTER: Guillou E
PROVIDER: S-EPMC3003199 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Genes & development 20101201 24
Genomic DNA is packed in chromatin fibers organized in higher-order structures within the interphase nucleus. One level of organization involves the formation of chromatin loops that may provide a favorable environment to processes such as DNA replication, transcription, and repair. However, little is known about the mechanistic basis of this structuration. Here we demonstrate that cohesin participates in the spatial organization of DNA replication factories in human cells. Cohesin is enriched a ...[more]