Pregabalin, the lidocaine plaster and duloxetine in patients with refractory neuropathic pain: a systematic review.

ABSTRACT:

Background

Patients frequently fail to receive adequate pain relief from, or are intolerant of, first-line therapies prescribed for neuropathic pain (NeP). This refractory chronic pain causes psychological distress and impacts patient quality of life. Published literature for treatment in refractory patients is sparse and often published as conference abstracts only. The aim of this study was to identify published data for three pharmacological treatments: pregabalin, lidocaine plaster, and duloxetine, which are typically used at 2(nd) line or later in UK patients with neuropathic pain.

Methods

A systematic review of the literature databases MEDLINE, EMBASE and CCTR was carried out and supplemented with extensive conference and grey literature searching. Studies of any desig

SUBMITTER: Plested M 

PROVIDER: S-EPMC3003252 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature