Arrhythmia caused by a Drosophila tropomyosin mutation is revealed using a novel optical coherence tomography instrument.

ABSTRACT:

Background

Dilated cardiomyopathy (DCM) is a severe cardiac condition that causes high mortality. Many genes have been confirmed to be involved in this disease. An ideal system with which to uncover disease mechanisms would be one that can measure the changes in a wide range of cardiac activities associated with mutations in specific, diversely functional cardiac genes. Such a system needs a genetically manipulable model organism that allows in vivo measurement of cardiac phenotypes and a detecting instrument capable of recording multiple phenotype parameters.

Methodology and principal findings

With a simple heart, a transparent body surface at larval stages and available genetic tools we chose Drosophila melanogaster as our model organism and developed for it a dual en-face

SUBMITTER: Ma L 

PROVIDER: S-EPMC3003684 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature