Exosomes communicate protective messages during oxidative stress; possible role of exosomal shuttle RNA.

ABSTRACT:

Background

Exosomes are small extracellular nanovesicles of endocytic origin that mediate different signals between cells, by surface interactions and by shuttling functional RNA from one cell to another. Exosomes are released by many cells including mast cells, dendritic cells, macrophages, epithelial cells and tumour cells. Exosomes differ compared to their donor cells, not only in size, but also in their RNA, protein and lipid composition.

Methodology/principal findings

In this study, we show that exosomes, released by mouse mast cells exposed to oxidative stress, differ in their mRNA content. Also, we show that these exosomes can influence the response of other cells to oxidative stress by providing recipient cells with a resistance against oxidative stress, observed as

SUBMITTER: Eldh M 

PROVIDER: S-EPMC3003701 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature