Vaccine delivery by polymeric vehicles in the mouse reproductive tract induces sustained local and systemic immunity.

ABSTRACT: Design of easily administered vaccines to protect the female reproductive tract against STIs such as HIV, HPV and HSV is a major step in improving world health standards. However, the effect of immunization routes and regimens (prime/boost) on immune response is not well-understood. Here, we present a systematic study of vaccine delivery by different routes and prime/boosting regimens to produce a robust humoral immune response in the reproductive tract. A model antigen, ovalbumin (OVA), was delivered orally or intranasally via polymer particles, and intravaginally via polymer disks to female mice. Repeated prime/boost at a single site result in high OVA-specific antibody levels in the serum for mice immunized orally (IgA) and invaginally (IgA and IgG) after 3 months. Vaginal antibody tite

SUBMITTER: Kuo-Haller P 

PROVIDER: S-EPMC3004023 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature