Genomewide linkage and peakwide association analyses of carotid plaque in Caribbean Hispanics.

ABSTRACT:

Background and purpose

Atherosclerosis is a complex subclinical cardiovascular disorder with a substantial genetic component. This study sought to identify genetic loci influencing carotid plaque in 2 independent samples.

Methods

B-mode ultrasound was performed to determine the presence and area of carotid plaque. Variance components analysis was used to test for linkage using 383 autosomal microsatellite markers in 1308 subjects from 100 Dominican families. Multiple linear and logistic regression models were used to investigate the association between plaque traits and 18,904 single nucleotide polymorphisms under the 1-logarithm of odds unit down regions of linkage peaks in an independent community-based data set (N = 941, 41% Dominicans) from the Northern Manhattan Study.<

SUBMITTER: Dong C 

PROVIDER: S-EPMC3004531 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature