Comparison of the expression of cytokine genes in the bursal tissues of the chickens following challenge with infectious bursal disease viruses of varying virulence.

ABSTRACT:

Background

Cytokines are important mediators and regulators of host responses against foreign antigen, with their main function to orchestrate the functional activities of the cells of the immune system. However little is known about the role of cytokines in pathogenesis and immune responses caused by infectious bursa disease virus (IBDV). The aim of this study was to examine the transcripts of cell-mediated immune response-related cytokine genes in the bursal tissues of chickens infected with IBDVs of varying virulence to gain an understanding of pathological changes and mechanisms of immunosuppression caused by IBDV infection and the immune responses evoked.

Results

Real-time quantitative PCR analysis revealed that the expression levels of both Th1 [interferon (IFN)-γ, int

SUBMITTER: Liu H 

PROVIDER: S-EPMC3004833 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature