Complement in patients receiving maintenance hemodialysis: functional screening and quantitative analysis.

ABSTRACT:

Background

The complement system is vital for innate immunity and is implicated in the pathogenesis of inflammatory diseases and the mechanism of host defense. Complement deficiencies occasionally cause life-threatening diseases. In hemodialysis (HD) patients, profiles on complement functional activity and deficiency are still obscure. The objectives of the present study were to measure the functional complement activities of the classical pathway (CP), lectin pathway (LP) and alternative pathway (AP) using a novel method and consequently to elucidate the rates of deficiencies among HD patients.

Methods

In the present study, 244 HD patients at one dialysis center and 204 healthy controls were enrolled. Functional complement activities were measured simultaneously using the W

SUBMITTER: Inoshita H 

PROVIDER: S-EPMC3004895 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature