Global turnover of histone post-translational modifications and variants in human cells.

ABSTRACT:

Background

Post-translational modifications (PTMs) on the N-terminal tails of histones and histone variants regulate distinct transcriptional states and nuclear events. Whereas the functional effects of specific PTMs are the current subject of intense investigation, most studies characterize histone PTMs/variants in a non-temporal fashion and very few studies have reported kinetic information about these histone forms. Previous studies have used radiolabeling, fluorescence microscopy and chromatin immunoprecipitation to determine rates of histone turnover, and have found interesting correlations between increased turnover and increased gene expression. Therefore, histone turnover is an understudied yet potentially important parameter that may contribute to epigenetic regulation. Un

SUBMITTER: Zee BM 

PROVIDER: S-EPMC3004898 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature