Characterization, phylogeny, alternative splicing and expression of Sox30 gene.

ABSTRACT:

Background

Members of the Sox gene family isolated from both vertebrates and invertebrates have been proved to participate in a wide variety of developmental processes, including sex determination and differentiation. Among these members, Sox30 had been considered to exist only in mammals since its discovery, and its exact function remains unclear.

Results

Sox30 cDNA was cloned from the Nile tilapia by RT-PCR and RACE. Screening of available genome and EST databases and phylogenetic analysis showed that Sox30 also exists in non-mammalian vertebrates and invertebrates, which was further supported by synteny analyses. Tissue expression in human, mouse and tilapia suggested that Sox30 was probably a gonad-specific gene, which was also supported by the fact that Sox30 EST sequen

SUBMITTER: Han F 

PROVIDER: S-EPMC3004900 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature