Matrix metalloproteinase activation predicts amelioration of remodeling after dietary modification in injured arteries.

ABSTRACT:

Objective

To establish and validate early noninvasive imaging of matrix metalloproteinase (MMP) activation for monitoring the progression of vascular remodeling and response to dietary modification.

Methods and results

Apolipoprotein E(-/-) mice that were fed a high-fat diet underwent left common carotid artery wire injury. One week after surgery, a group of animals were withdrawn from the high-fat diet. The other group of animals continued that diet throughout the study. Micro single-photon emission computed tomographic (microSPECT)/CT imaging with RP805 (a (99m)Tc-labeled tracer targeting activated MMPs) was repeatedly performed at 2 and 4 weeks after surgery. Histological analysis at 4 weeks showed significant left carotid neointima formation, monocyte/macrophage infiltra

SUBMITTER: Tavakoli S 

PROVIDER: S-EPMC3005135 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature