The anti-inflammatory cytokine interleukin 19 is expressed by and angiogenic for human endothelial cells.

ABSTRACT:

Objective

To characterize the expression and function of interleukin (IL) 19, a recently described T-helper 2 anti-inflammatory IL, on endothelial cell (EC) pathophysiological features.

Methods and results

The expression and effects of anti-inflammatory ILs on EC activation and development of angiogenesis are uncharacterized. We demonstrate by immunohistochemistry and immunoblot that IL-19 is expressed in inflamed, but not normal, human coronary endothelium and can be induced in cultured human ECs by serum and basic fibroblast growth factor. IL-19 is mitogenic and chemotactic, and it promotes EC spreading. IL-19 activates the signaling proteins STAT3, p44/42, and Rac1. In functional ex vivo studies, IL-19 promotes cordlike structure formation of cultured ECs and enhances mic

SUBMITTER: Jain S 

PROVIDER: S-EPMC3005139 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature