Enantioselective synthesis of (-)-sclerophytin A by a stereoconvergent epoxide hydrolysis.

ABSTRACT: The cytotoxic natural product (-)-sclerophytin A was constructed in 13 steps from geranial. Highlights from the synthesis are a stereoselective Oshima-Utimoto reaction, a Shibata-Baba indium-promoted radical cyclization, and a novel stereoconvergent epoxide hydrolysis.

SUBMITTER: Wang B 

PROVIDER: S-EPMC3005712 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature