Evolutionary patterns of amino acid substitutions in 12 Drosophila genomes.

ABSTRACT:

Background

Harnessing vast amounts of genomic data in phylogenetic context stemming from massive sequencing of multiple closely related genomes requires new tools and approaches. We present a tool for the genome-wide analysis of frequencies and patterns of amino acid substitutions in multiple alignments of genes' coding regions, and a database of amino acid substitutions in the phylogeny of 12 Drosophila genomes. We illustrate the use of these resources to address three types of evolutionary genomics questions: about fluxes in amino acid composition in proteins, about asymmetries in amino acid substitutions and about patterns of molecular evolution in duplicated genes.

Results

We demonstrate that amino acid composition of Drosophila proteins underwent a significant shift ove

SUBMITTER: Yampolsky LY 

PROVIDER: S-EPMC3005911 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature