Cytokine dysregulation in early- and late-term placentas from feline immunodeficiency virus (FIV)-infected cats.

ABSTRACT:

Problem

Experimental infection of cats with FIV-B-2542 produces high rates of fetal infection and reproductive failure. We hypothesized that dysregulation of placental cytokine expression occurs in FIV-infected queens, and aberrant expression potentiates inflammation and impacts pregnancy outcome. Our purpose was to quantify expression of representative pro-inflammatory cytokines (IL-6, IL-12p35, and IL-1β), IL-10 (anti-inflammatory), and the chemokine SDF-1α in early- and late-term placental tissues.

Method of study

 Real-time reverse transcriptase PCR was used to measure gene expression in placental tissues.

Results

 Increased expression of IL-6 and IL-12p35 and decreased expression of IL-10 occurred in FIV-infected tissues at early pregnancy; at late gestation, IL-

SUBMITTER: Scott VL 

PROVIDER: S-EPMC3005979 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature