Helicobacter pylori CagA inhibits PAR1-MARK family kinases by mimicking host substrates.

ABSTRACT: The CagA protein of Helicobacter pylori interacts with numerous cellular factors and is associated with increased virulence and risk of gastric carcinoma. We present here the cocrystal structure of a subdomain of CagA with the human kinase PAR1b/MARK2, revealing that a CagA peptide mimics substrates of this kinase family, resembling eukaryotic protein kinase inhibitors. Mutagenesis of conserved residues central to this interaction renders CagA inactive as an inhibitor of MARK2.

SUBMITTER: Nesic D 

PROVIDER: S-EPMC3006182 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature