Coxiella burnetii transcriptional analysis reveals serendipity clusters of regulation in intracellular bacteria.

ABSTRACT: Coxiella burnetii, the causative agent of the zoonotic disease Q fever, is mainly transmitted to humans through an aerosol route. A spore-like form allows C. burnetii to resist different environmental conditions. Because of this, analysis of the survival strategies used by this bacterium to adapt to new environmental conditions is critical for our understanding of C. burnetii pathogenicity. Here, we report the early transcriptional response of C. burnetii under temperature stresses. Our data show that C. burnetii exhibited minor changes in gene regulation under short exposure to heat or cold shock. While small differences were observed, C. burnetii seemed to respond similarly to cold and heat shock. The expression profiles obtained using microarrays produced in-house were confirmed by quan

SUBMITTER: Leroy Q 

PROVIDER: S-EPMC3006202 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature