CCL2 and CCR2 variants are associated with skeletal muscle strength and change in strength with resistance training.

ABSTRACT: Baseline muscle size and muscle adaptation to exercise are traits with high variability across individuals. Recent research has implicated several chemokines and their receptors in the pathogenesis of many conditions that are influenced by inflammatory processes, including muscle damage and repair. One specific chemokine, chemokine (C-C motif) ligand 2 (CCL2), is expressed by macrophages and muscle satellite cells, increases expression dramatically following muscle damage, and increases expression further with repeated bouts of exercise, suggesting that CCL2 plays a key role in muscle adaptation. The present study hypothesizes that genetic variations in CCL2 and its receptor (CCR2) may help explain muscle trait variability. College-aged subjects [n = 874, Functional Single-Nucleotide Polym

SUBMITTER: Harmon BT 

PROVIDER: S-EPMC3006412 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature