Ontology highlight
ABSTRACT:
SUBMITTER: Boyer LA
PROVIDER: S-EPMC3006442 | biostudies-literature | 2005 Sep
REPOSITORIES: biostudies-literature
Cell 20050901 6
The transcription factors OCT4, SOX2, and NANOG have essential roles in early development and are required for the propagation of undifferentiated embryonic stem (ES) cells in culture. To gain insights into transcriptional regulation of human ES cells, we have identified OCT4, SOX2, and NANOG target genes using genome-scale location analysis. We found, surprisingly, that OCT4, SOX2, and NANOG co-occupy a substantial portion of their target genes. These target genes frequently encode transcriptio ...[more]