Model for comparative analysis of antigen receptor repertoires.

ABSTRACT: In modern molecular biology one of the standard ways of analyzing a vertebrate immune system is to sequence and compare the counts of specific antigen receptor clones (either immunoglobulins or T-cell receptors) derived from various tissues under different experimental or clinical conditions. The resulting statistical challenges are difficult and do not fit readily into the standard statistical framework of contingency tables primarily due to the serious under-sampling of the receptor populations. This under-sampling is caused, on one hand, by the extreme diversity of antigen receptor repertoires maintained by the immune system and, on the other, by the high cost and labor intensity of the receptor data collection process. In most of the recent immunological literature the differences acro

SUBMITTER: Rempala GA 

PROVIDER: S-EPMC3006491 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature