Characterization of JG024, a pseudomonas aeruginosa PB1-like broad host range phage under simulated infection conditions.

ABSTRACT:

Background

Pseudomonas aeruginosa causes lung infections in patients suffering from the genetic disorder Cystic Fibrosis (CF). Once a chronic lung infection is established, P. aeruginosa cannot be eradicated by antibiotic treatment. Phage therapy is an alternative to treat these chronic P. aeruginosa infections. However, little is known about the factors which influence phage infection of P. aeruginosa under infection conditions and suitable broad host range phages.

Results

We isolated and characterized a phage, named JG024, which infects a broad range of clinical and environmental P. aeruginosa strains. Sequencing of the phage genome revealed that the phage JG024 is highly related to the ubiquitous and conserved PB1-like phages. The receptor of phage JG024 was determined as

SUBMITTER: Garbe J 

PROVIDER: S-EPMC3008698 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature